Depletion of SOX2 by RNAi results in downregulation of stem cell markers and induction of amoeboid migration mode in human glioma cells

A. Temme, F. Oppel & G. Schackert
Objective: Recently, we have detected the stem cell marker SOX2 in a subset of tumor cells in glioblastoma multiforme (GBM). SOX2 represents a transcription factor which has attracted growing attention since it contributes to the maintenance of pluripotent adult neural stem cells. Its expression in [for full text, please go to the a.m. URL]