CX3CL1-CX3CR1 mediated cross talk between glioma infiltrating microglia (GIMs) and human glioma cells promotes GIM recruitment

K. Hattermann, R. Mentlein, F. Knerlich-Lukoschus, M. Mehdorn & J. Held-Feindt
Objective: A significant characteristic of the highly malignant glioblastoma brain tumors is the marked presence of glioblastoma infiltrating microglia/macrophages (GIMs). Since microglia cells are known to express the fraktalkine receptor CX3CR1 and astrocytes are noted for CX3CL1 expression itself[for full text, please go to the a.m. URL]