Inhibition of Tissue Factor signalling suppresses proliferation, migration and invasion of low- and high-grade glioma cells

F. Geßler, V. Voss, S. Dützmann, V. Seifert, R. Gerlach & D. Kögel
Objective: Almost all patients with low grade gliomas suffer from recurrent tumors and malignisation over the years. Cell signalling and mechanisms leading to transformation from low to high grade gliomas are not yet understood. Tissue Factor (TF) is activated by hypoxia and its expression positively[for full text, please go to the a.m. URL]