Mismatch repair protein status (MLH1, MSH2, MSH6) in paired initial and recurrent glioblastoma

A. Stark, A. Doukas, H-H. Hugo & H.M. Mehdorn
Objective: There is evidence that defective DNA mismatch repair (MMR) results in tolerance to temozolomide regardless of O(6)-alkylguanine-DNA alkyltransferase (AGT) activity. Dysfunction of MMR genes, in particular MLH1, MSH2, and MSH6, leads to loss of MMR protein expression and to microsatellite [for full text, please go to the a.m. URL]