Prognostic relevance of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from glioblastomas after primary concomitant radiochemo-therapy followed by adjuvant temozolomide

N. Thon, S. Eigenbrod, R. Egensperger, H. Kretzschmar, J. Lutz, J.-C. Tonn & F.-W. Kreth
Objective: Epigenetic silencing of the MGMT gene has been linked to favorable prognosis in glioblastomas (GBM) after treatment according to the EORTC protocol even when stratified for the extent of surgery except for patients who undergo biopsy only. Aim of this study was to evaluate the prognostic [for full text, please go to the a.m. URL]