Genetic variants of genes encoding for extracellular matrix enzymes in the pathogenesis of intracranial aneurysms

D. Krex, K. Kotteck, I. König, H. Schackert & G. Schackert
Objective: There are several lines of evidence that remodeling of the extracellular matrix (ECM) is a crucial event in the pathogenesis of intracranial aneurysms (IA). Matrix-metalloproteinases (MMPs) are the most important degrading enzymes in the extracellular matrix. There are conflicting results[for full text, please go to the a.m. URL]