Transferrin receptor mediated iron accumulation controls proliferation and glutamate release in glioma cells

D. Markovic, G. Rainer, S. Michael, C. Sridhar, K. Jürgen & K. Helmut
Objective: To determine whether chemical manipulation of intracellular iron influences malignant behavior of glioma cells. Methods: Proliferation measurements by BrdU test, ROS level measurements using H2DCFDA, Western blotting, immunoprecipitation, in vivo U373 glioma model, immunofluorescence microscopy.[for full text, please go to the a.m. URL]