Growth mechanisms of CNS hemangioblastomas

S. Gläsker, A. Vortmeyer, B. Schatlo, R. Lonser & R. Pluta
Objective: Patients with von Hippel-Lindau (VHL) disease develop multifocal CNS hemangioblastomas due to the inactivation of the VHL tumor suppressor gene. Recent studies indicate that VHL inactivation and subsequent up-regulation of hypoxia inducible factor (HIF) alone is insufficient to promote neoplastic[for full text, please go to the a.m. URL]