Cav2.1 S218L mutant mice reveal increased secondary brain damage after mild traumatic brain injury

N. Terpolilli, A. Van Den Maagdenberg, B. Todorov, M. Ferrari & N. Plesnila
Objective: About 50% of the patients suffering from Familiar Hemiplegic Migraine have missense mutations in the CACNA1A gene that encodes the pore forming subunit of neuronal voltage-gated Cav2.1 (P/Q-type)Ca2+ channels. CACNA1A FHM mutations lead to a gain of function of Cav2.1 Ca2+[for full text, please go to the a.m. URL]