Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and PKC signaling

M. Kotter, A. Baer & Y. Syed
Objective: Failure of oligodendrocyte precursor cell (OPC) differentiation contributes significantly to failed myelin sheath regeneration (remyelination) in demyelinating diseases such as trauma, stroke and multiple sclerosis. Although the reasons for this failure are not completely understood, several[for full text, please go to the a.m. URL]