Glycolysis causes invasion of glioblastoma cells by increased secretion of cathepsinB

M. Proescholdt, M. Al-Zabin, E.M. Störr, A. Lohmeier & A. Brawanski
Objective: Malignant gliomas show high rates of glycolysis caused by hypoxia and specific gene alterations. This leads to high glucose utilization rates combined with increased levels of lactic acid. We hypothesized that hypoxia-inducible carbonic anhydrase (CA) IX is involved in the extrusion of hydrogen[for full text, please go to the a.m. URL]