Antiproliferative activity of JS-K, a glutathione S-transferase alpha-activated nitric oxide donor, in human glioblastomas in vitro

A. Weyerbrock, B. Baumer, E. Kogias & A. Papazoglou
Objective: Glutathione S-transferases (GSTs) play an important role in multidrug resistance. The diazeniumdiolate JS-K generates nitric oxide (NO) after enzymatic activation by GST-alpha and has a dose-dependent antiproliferative effect in U87 glioma cells, and induces sensitization to imatinib (Glivec®)[for full text, please go to the a.m. URL]