Attenuation of tumor growth and antiangiogenic effects of the nitric oxide donor JS-K in U87 gliomas in vivo

A. Weyerbrock, N. Psarras, B. Baumer, E. Kogias & A. Papazoglou
Objective: The diazeniumdiolate JS-K generates nitric oxide (NO) after enzymatic activation by GST and has potent growth-inhibitory effects in U87 glioma cells and induced chemosensitization to imatinib (Glivec®) in vitro. The objective was to evaluate this approach in vivo. Methods: Nude rats[for full text, please go to the a.m. URL]