Platelet depletion does not influence growth and angiogenesis of GBM in vivo despite proliferative and migratory effects of platelet cytokines in vitro

M. Brockmann, B. Bender, E. Plaxina, I. Nölte, R. Erber, S. Schambach, C. Groden & L. Schilling
Objective: Thrombocytosis is an independent predictor of short survival in patients with glioblastoma (GBM) and in various other tumor entities. Prothrombotic activity of the tumor microcirculation has been suggested to induce platelet activation resulting in a release of angiogenic cytokines from activated[for full text, please go to the a.m. URL]