Metamizole (Dipyrone) Induced Acute Agranulocytosis – How rare is it really? Preliminary results from the National Pharmacovigilance-Center Berlin (PVZ-FAKOS)

E. Bronder, A. Klimpel, F. Andersohn & E. Garbe
Background and aim: Despite the well-known risk of acute agranulocytosis, ambulatory prescriptions of metamizole raised from 32.2 Mio. Defined Daily Doses (DDD) in 2000 to 85.8 Mio. DDD in 2007 (+166%). The total number of German adult patients with metamizole induced agranulocytosis leading[for full text, please go to the a.m. URL]