Blinded sample size reestimation with count data: Methods and applications in multiple sclerosis

Tim Friede & Heinz Schmidli
Sample size estimation in clinical trials depends critically on nuisance parameters such as variances or overall event rates, which have to be guessed or estimated from previous studies in the planning phase of a trial. Blinded sample size reestimation estimates these nuisance parameters based on blinded[for full text, please go to the a.m. URL]