Activation of Mark-Pathways in head and neck squamous cell carcinomas after irradiation: part of a rescue mechanism?

Annette Affolter, Jürgen Brieger & Wolf J. Mann
Introduction: Irradiation is a fundamental part of head and neck squamous cell carcinoma (HNSCC) therapy. However, tumour response is limited. We analyzed intracellular signalling pathways which are stimulated by irradiation, in particular MAPK cascades. The aim was to define potentially activated rescue[for full text, please go to the a.m. URL]