The C825T polymorphism of the G Protein β3 subunit (GNB3) is a prognostic parameter for relapse-free and overall survival of patients with HNSCC

Götz Frederik Lehnerdt, Agnes Bankfalvi, Peter Franz, Sara Grehl, Stephan Lang, Kurt Werner Schmid, Winfried Siffert, Klaus Jahnke & Ulrich H. Frey
The T-allele of a common C825T single nucleotide polymorphism (SNP) in the gene GNB3, encoding the G 3 subunit of heterotrimeric G-proteins, is associated with a truncated form of the G 3 protein that imparts a greater signaling capacity than the alternative C-allele encoding a non-truncated protein.[for full text, please go to the a.m. URL]