Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines: Radiobiological Basis for a Phase II Clinical Study Protocol (CLEOPATRA)

S. Combs, M. Kieser, W. Wick, A. Unterberg, J. Bohl, T. Elsässer, K.-J. Weber, D. Schulz-Ertner, W. K. Weyrather & J. Debus
Purpose: To investigate the cytotoxic effect of high linear-energy transfer (LET) carbon irradiation on glioblastoma cells lines in combination with temozolomide (TMZ) and to generate a radiobiological basis for subsequent clinical trials. Methods and materials: The cell lines U87-MG expressing wild-type[for full text, please go to the a.m. URL]