Differential DNA Repair Mechanisms in Response to Proton and Photon Irradiation

N. Frenzel, E. Hug, A. Lomax, A. Staab, A. Sartori & M. Pruschy
Purpose/objective(s): A relative biological effectiveness (RBE) factor for proton irradiation of 1.1–1.2 is presently used in clinical proton radiotherapy. However, the molecular damage pattern and damage response, which are the basis of this RBE value remain largely unknown. We investigated[for full text, please go to the a.m. URL]