GSK-3-beta inhibition ameliorates the course of experimental DSS-colitis in vivo

Mike Georg Laukötter, Porfirio Nava, Charles A. Parkos & Asma Nusrat
Introduction: Intestinal barrier function is maintained by epithelial cell proliferation which is regulated by Wnt/β-catenin signaling. This canonical pathway acts through stabilization of β-catenin. In absence of Wnt, β-catenin is constantly phosphorylated by a destruction protein[for full text, please go to the a.m. URL]