Non-viral gene therapy for regeneration in an ischemic flap model

Alex Slobodianski, Christoph Hartog, Astrid Kathöfer, Jessica Frenz, Ziyang Zhang, Peter Mailänder & Hans-Günther Machens
Introduction: We established a cell-based, non viral gene-transfer method using fibroblasts to temporarily produce bFGF and VEGF165 in ischemic tissue. Protein delivery from transfected cells can induce expression of tissue inductive factors to stimulate the cellular processes required for regeneration.[for full text, please go to the a.m. URL]