Concurrent inhibition of TGF- and MAP kinase pathways lead to abrogated fibrotic traits of Dupuytren’s disease fibroblasts

Carola Krause, Peter Kloen, Christian Krause, Erik De Vink, Petra Knaus & Peter Ten Dijke
Fragestellung: Which signaling pathways drive the fibro-proliferation of Dupuytren’s disease? Do chemical compounds that selectively inhibit these pathways give raise for possible non-surgical treatment strategies? Methodik: Immunohistochemistry, Immunofluorescence, primary cell [for full text, please go to the a.m. URL]