Hedgehog signalling in malignant glioma – a potential new target for adjuvant chemotherapy?

Stefanie Braun, Christof Renner, Jürgen Meixensberger & Frank Gaunitz
Objective: The Hedgehog signalling pathway is important for the development of the central nervous system. On the other hand, aberrant induction is observed in different tumors. Immunofluorescence and RT-PCR confirmed that in some gliomas Gli1, a transcription factor activated by signalling, is present.[for full text, please go to the a.m. URL]