MGMT mRNA expression predicts clinical outcome in malignant glioma after radiotherapy and/or chemotherapy independent of MGMT promoter methylation

Niklas Thon, Simone Kreth, Sabina Eigenbrod, Hans Kretzschmar, Joerg C. Tonn & Friedrich W. Kreth
Objective: Epigenetic silencing of the gene that encodes for O6-Methylguanine-DNA-methyltransferase (MGMT) has been correlated with favourable clinical outcome in patients with malignant gliomas after radio-/chemotherapy using alkylating agents such as temozolomide; It has been hypothesized that[for full text, please go to the a.m. URL]