The role of MAD2A in mitotic spindle checkpoint function and for survival of glioblastoma cells

Almuth Keßler, Carsten Hagemann, Stefanie Gerngras, Rajnikant Patel, Ralf-Ingo Ernestus & Giles Hamilton Vince
Objective: MAD2A is a key regulator of the mitotic spindle checkpoint, which controls fidelity of spindle fiber attachment to sister chromatides. Defects in this checkpoint may contribute to chromosomal instability and may be involved in tumorigenesis. Since human malignant gliomas are highly aneuploid,[for full text, please go to the a.m. URL]