Association of the CC genotype of the regulatory Bcl-2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme

Nicolai El Hindy, Hagen S. Bachmann, Nicole Lambertz, Ulrich Sure, Winfried Siffert & I. Erol Sandalcioglu
Objective: Bcl-2 plays a key role in the downregulation of apoptosis and proliferation, as well as increased chemoresistance in glioblastoma multiforme (GBM). We investigated the role of a common regulatory single-nucleotide polymorphism (-938C>A) which is located in the inhibitory P2 promoter [for full text, please go to the a.m. URL]