Cytoplasmic sublocalization of the stem cell-associated protein ASPM is an independent prognostic factor in astrocytic gliomas

Christine Dictus, Benito Campos, Rezvan Ahmadi, Justo Lorenzo Bermejo, Christel Herold-Mende & Andreas Unterberg
Objective: Recently, tumour initiation, tumour recurrence and therapy-resistance in astrocytic gliomas have been attributed to the existence of brain tumour stem-like cells. ASPM (abnormal spindle-like, microcephaly associated), a stem-cell associated protein, is a key regulator of the symmetric division[for full text, please go to the a.m. URL]