Chloroquine sensitizes experimental gliomas derived from brain tumor initiating stem-like cells to radiation therapy

Alf Giese, Julia Pruefer, Veit Rohde, Margret Rave-Fraenk, Walter Schulz-Schaeffer & Ella Kim
Objective: The survival of patients with glioblastoma remains low because of resistance of glioma cells to radiation and chemotherapy. Brain Tumour Initiating Cells (BTICs) have been implicated in the posttherapy recurrence of gliomas. The antimalaria and antirheumatic drug chloroquine (ClQ) has recently[for full text, please go to the a.m. URL]