Glioma-induced Toll like receptors (TLR) signaling in microglia promotes parenchymal MT1-MMP expression and tumor expansion in vivo

Darko Markovic, Michael Synowitz, Rainer Glass, Helmut Kettenmann & Jürgen Kiwit
Objective: We have shown previously that membrane type 1 metalloprotease (MT1-MMP) is upregulated in glioma associated microglia, but not in the glioma cells and that a glioma released factor is stimulating via p38 MAPK overexpression of MT1-MMP in microglia. Now, we investigate with a novel glioma [for full text, please go to the a.m. URL]