Genetic risk profiles identify different molecular etiologies for glioma

Matthias Simon, Fay J. Hosking, Yannick Marie, Konstantin Gousias, Blandine Boisselier, Catherine Carpentier, Johannes Schramm, Karima Mokhtari, Khe Hoang-Xuan, Ahmed Idbaih, Jean-Yves Delattre, Mark Lathrop, Lindsay B. Robertson, Richard S. Houlston & Marc Sanson
Objective: Genome-wide association studies have recently identified single nucleotide polymorphisms in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1) and 11q23.3 (rs498872, PHLDB1) to be associated with glioma [for full text, please go to the a.m. URL]