Treatment of cerebral vasospasm after experimental subarachnoid hemorrhage using intracisternal heme-oxygenase-1(HO-1) fused to a arginine protein transporter domain

Tomoyuki Ogawa, Daniel Hänggi & Hans Jakob Steiger
Objective: Heme-oxygenase-1(HO-1) is a 32 kDa enzyme involved in heme-catabolism and cleaves heme to form biliverdin and carbon monoxide (CO). HO-1 is said to reduce the contractile effect of hemoglobin. A sequence of 11 consecutive arginine groups (11R) is one of the most effective protein transduction[for full text, please go to the a.m. URL]