Cortical spreading depolarization triggers delayed ischemic neurological deficit in absence of proximal vasospasm in patients with aneurysmal subarachnoid hemorrhage

Johannes Woitzik, Jens P. Dreier, Nils Hecht, Ingo Fiss, Jerome Manville, Peter Schmiedek, Michael Diepers, Elke Muench, Hidetoshi Kasuya, Peter Vajkoczy & COSBID Study Group
Objective: Cortical Spreading Depolarization (CSD) was measured in close association with delayed ischemic neuronal deficit (DIND) in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the assumed prime mechanism of DIND is the induction of proximal vasospasm triggered by breakdown products[for full text, please go to the a.m. URL]