Dynamics in the influence of sedatives on spreading depolarizations in patients after acute brain injury

Daniel Hertle, Jed Hartings, Jens Dreier, Anthony Strong, Andreas Unterberg, Oliver Sakowitz & COSBID Group
Objective: Spreading Depolarizations (SD) are frequently recorded in proximity of cortical injury sites. Most patients with severe brain injury are under sedation and analgesia. The influence of sedatives on electric brain activity is well known, but has not been investigated for SDs in brain-injured[for full text, please go to the a.m. URL]