Age-dependence of arteriogenesis and hemodynamic compensation during chronic cerebral ischemia

Nils Hecht, Johannes Woitzik, Marc-Michael Müller, Melina Nieminen-Kelhä & Peter Vajkoczy
Objective: Unilateral internal carotid artery occlusion (ICAO) induces spontaneous arteriogenesis in C57/BL6 mice. However, little is known about the impact of age on the capacity for hemodynamic compensation and collateral vessel growth. The present study tests this effect in a model of chronic[for full text, please go to the a.m. URL]