IDH1 and IDH2 mutations and their role in progression of low grade and malignant gliomas

Tareq Juratli, Katja Robel, Gabriele Schackert & Dietmar Krex
Objective: Somatic mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are frequently found in secondary glioblastoma (sGBM) and are of prognostic value. In primary glioblastoma (pGBM), IDH1 and IDH2 mutations are rare. It is yet unclear whether IDH1 and/or IDH2 mutations[for full text, please go to the a.m. URL]