Growth factor-dependence of stem cell-like cells from malignant brain tumors

Isabel Choschzick, Alexander Bernt, Sarah Willkomm, Volker Tronnier & Christina Zechel
Objective: Malignant brain tumors are amongst the most lethal solid tumors. It has been proposed that cells with stem cell features contribute to the initiation and progression of primary malignant brain tumors and recurrent glioma. However, it remains elusive how their growth is regulated and how stem[for full text, please go to the a.m. URL]