Vascular targeting strategies using F8-SIP antibody against the ED-A domain of fibronectin in glioma angiogenesis

Marcus Czabanka, Gueliz Parmaksiz, Alessandro Palumbo, Axel Ullrich, Dario Neri & Peter Vajkoczy
Objective: Vascular targeting strategies have become a promising approach for tumor diagnostics and therapy. The alternatively spliced extra domain A (ED-A) of fibronectin represents a promising neoangiogenic marker in this concept. The aim of our study was to characterize biodistribution characteristics[for full text, please go to the a.m. URL]