A role for system Xc- in brain edema formation in malignant gliomas

Ilker Y. EyĆ¼poglu, Thomas Broggini, Tobias Engelhorn, Nic E. Savaskan & Michael Buchfelder
Objective: Glutamate is a serum derived factor that promotes cell growth and proliferation in various cancer entities. Moreover, in the CNS glutamate also evokes neuronal cell death at high concentrations. A hallmark of malignant brain tumors is their possibility to induce a peritumoral edema or brain[for full text, please go to the a.m. URL]