T-cell infiltration impact on GBM patient survival and its impairment by TGF- β1 and -β2

Jennifer Lohr, Rezvan Ahmadi, Andrea Huppertz, Stefan Grau, Christel Herold-Mende & Andreas Unterberg
Objective: In the last decades, immunotherapeutical approaches have been successfully designed with the aim of inducing anti-glioma T-cell responses. As a prerequisite for a therapeutical effect, T-cells need to overcome the endothelial barrier. The purpose of this study was to investigate whether pre-existing[for full text, please go to the a.m. URL]