Aberrant retinoic acid signaling in gliomas contributes to tumor malignancy

Benito Campos, Franz-Simon Centner, Justo Lorenzo Bermejo, Katharina Dorsch, Christel C. Herold-Mende & Andreas Unterberg
Objective: In gliomas, undifferentiated tumor cells influence tumor growth and seem to be irresponsive to physiological differentiation stimuli, persisting in an undifferentiated developmental state associated with high tumorigenicity and therapy resistance. Here we investigated potential disruptions[for full text, please go to the a.m. URL]