VEGFR-3 pathway as a possible escape mechanism from anti-VEGF-A therapy in glioblastoma

Jun Thorsteinsdottir, Jörg-Christian Tonn, Christian Schichor & Stefan Grau
Objective: Neo-angiogenesis in gliomas is related to the expression of VEGF-A and its receptor VEGFR-2. Anti-VEGF-A therapy in combination with chemotherapy is an emerging treatment concept for malignant glioma. In various animal glioma models, anti-VEGF-A-therapy, e.g. with bevacizumab, a neutralizing[for full text, please go to the a.m. URL]