Grade dependent expression of CD146/MCAM (melanoma cell adhesion molecule) in gliomas identifies mesenchymal progenitor cells as well as endothelial cells

Valerie Albrecht, Kathrin Jürchott, Joachim Selbig, Jörg-Christian Tonn & Christian Schichor
Objective: Malignant gliomas are characterized by invasion, angiogenesis and recruitment of bone marrow derived progenitor cells. In non-glial tumors, CD146 was shown to serve as a key cell adhesion protein in vascular endothelial cell activity but also as a membrane signal receptor in tumor-induced[for full text, please go to the a.m. URL]