Hypoxia-driven erythropoietin-crosstalk between bone marrow derived mesenchymal progenitor cells and malignant gliomas

Florian Faber, Valerie Albrecht, Ketai Guo, Kathrin Juerchott, Jörg-Christian Tonn & Christian Schichor
Objective: Enhanced proliferation, metabolic stress, necrosis and hypoxia are hallmarks of malignant gliomas. Tumor cells produce a broad variety of factors in order to escape cell death through the loss of oxygenation, such as hypoxia-inducible factor 1 alpha (HIF1 α) and erythropoietin (EPO)[for full text, please go to the a.m. URL]