Multiple intravenous injections of oncolytic Parvovirus H-1 lead to complete tumor regression of rat and human glioma xenografts similar to intratumoral therapy

Karsten Geletneky, Irina KiprianovaI, Ali Ayache, Regina Koch, Soner Muhcu, Clemens Sommer, Nadja Thomas, Andreas Unterberg, Jean Rommelaere & Jörg R. Schlehofer
Objective: The treatment of malignant gliomas remains an unsolved problem requiring alternative treatment modalities. The use of oncolytic viruses that specifically target and destroy tumor cells is under investigation also for glioblastomas. One candidate virus for glioma therapy is the rodent parvovirus[for full text, please go to the a.m. URL]