Cytotoxic effects of statins and thiazolidinediones on meningioma cells

Sonja Gehring, Jorge Humberto Tapia-Pérez, Elmar Kirches, Raimund Firsching, Gerburg Keilhoff, Thomas Schneider & Christian Mawrin
Objective: Statins are inhibitors of the cholesterol pathway with pleiotropic effects, while thiazolidinediones (TDZ) are peroxisomal proliferator activator receptor gamma (PPAR-gamma) agonists with potent pro-apoptotic activity. For both kinds of drugs, a cytotoxic effect against several human tumours[for full text, please go to the a.m. URL]