C-kit expression in meningioma and growth inhibition by imatinib in vitro

Oliver Heese, Alina Boberg, Jakob Matschke, Marcus Glatzel, Manfred Westphal & Katrin Lamszus
Objective: In spite of modern neurosurgical and radiosurgical strategies, meningiomas may recur and have a prolonged impact on the quality of life. So far effective chemotherapy protocols do not exist, in particular since molecular targets have not been identified. C-kit, a receptor tyrosine-kinase [for full text, please go to the a.m. URL]