A microarray-based DNA methylation analysis of brain metastases and their corresponding primary carcinomas

Ramón Martínez, Veit Rohde, Angelika Gutenberg, Laszlo Füzesi, José Martín-Subero & Manel Esteller
Objective: Aberrant gene methylation has been linked to metastasis through promoting mitotic recombination, deletions and chromosomal rearrangements. It leads to the repression of gene expression that enables tumor cells to metastasize or have a selective advantage at the secondary tissue site. The [for full text, please go to the a.m. URL]