Loss of CCM2, but not CCM3, impairs the integrity of endothelial tube structure – An association with the incidence of intracerebal haemorrhage of inherited cerebral cavernous malformations (CCMs)?

Yuan Zhu, Jin-Fang Xu, Dorothea Miller, I. Erol Sandalcioglu & Ulrich Sure
Objective: Mutations in CCM genes may cause autosomal dominant cerebral cavernous malformations (CCMs). Indeed, a different intracranial hemorrhage rate has been observed in CCMs carrying individual CCM gene mutations. We proposed a differential regulation of angiogenesis by these disease genes. The[for full text, please go to the a.m. URL]