Two-dose evaluation of efficacy and safety of perfluorocarbon Oxycyte™ in diffuse traumatic brain injury in the rat

Amadé Bregy, Mileydis Zambrana, Julio Cesar Diaz, Amanpreet Singh, W. Dalton Dietrich, Ross M. Bullock, Andreas Raabe & Michael Reinert
Objective: Approximately 1/3 of severe brain injury patients show reduced brain oxygen tension (<25 mmHg) often due to reduced cerebral blood flow, during the first 24 hours following injury, leading to post-traumatic brain damage and a worse outcome. These secondary insults include hypoxia,[for full text, please go to the a.m. URL]